People take mugwort root as a “tonic” and to boost energy.

People take the rest of the plant for stomach and intestinal conditions including colic, diarrhea constipation, cramps, weak digestion, worm infestations, and persistent vomiting. Mugwort is also used to stimulate gastric juice and bile secretion. It is also used as a liver tonic; to promote circulation; and as a sedative. Other uses include treatment of hysteria, epilepsy, and convulsions in children. Women take mugwort for irregular periods and other menstruation problems.

In combination with other ingredients, mugwort root is used for mental problems (psychoneuroses), ongoing fatigue and depression (neurasthenia), depression, preoccupation with illness (hyperchronic), general irritability, restlessness, trouble sleeping (hypertension), and anxiety.